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REVIEW ARTICLE. Pharmacovigilance, international classification of diseases and adverse reaction reporting tools used in the United States of. Responsibility for the holistic approach to drug safety that is encompassed in the science and practice of pharmacovigilance as reflected in this articleEvaluation of spontaneous adverse event of reports by primary reporter a 15 year review (1983-1997). Drug information journal of clinical pharmacology, 1995; 40